Whole-brain ex-vivo quantitative MRI of the cuprizone mouse model
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منابع مشابه
Whole-brain ex-vivo quantitative MRI of the cuprizone mouse
11 Myelin is a critical component of the nervous system and a major contributor to contrast in Magnetic Resonance (MR) images. However the precise contribution of myelination to multiple MR modalities is still under debate. The cuprizone mouse is a well established model of demyelination that has been used in several MR studies, but these have often imaged only a single slice and analysed a sma...
متن کاملWhole-brain ex-vivo quantitative MRI of the cuprizone
11 Myelin is a critical component of the nervous system and a major contributor to contrast in Magnetic Resonance (MR) images. However the precise contribution of myelination to multiple MR modalities is still under debate. The cuprizone mouse is a well established model of demyelination that has been used in several MR studies, but these have often imaged only a single slice and analysed a sma...
متن کاملWhole-brain ex-vivo quantitative MRI of the cuprizone mouse model
Myelin is a critical component of the nervous system and a major contributor to contrast in Magnetic Resonance (MR) images. However, the precise contribution of myelination to multiple MR modalities is still under debate. The cuprizone mouse is a well-established model of demyelination that has been used in several MR studies, but these have often imaged only a single slice and analysed a small...
متن کاملMonitoring Demyelination in a Cuprizone Mouse Model with Longitudinal and Quantitative MRI Measurements
Introduction Magnetic resonance imaging (MRI) methods capable of quantifying changes due to demyelination can improve both the diagnosis and understanding of white matter diseases such as multiple sclerosis. T2-weighted (T2w) and magnetization transfer images (MTI) were acquired weekly in control (n=4) and cuprizone-fed mice (n=4). Diffusion tensor imaging (DTI), quantitative MTI, high-resoluti...
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Ex-vivo brain quantitative susceptibility mapping (QSM) allows investigation of brain characteristics at essentially the same point in time as histopathologic examination, and therefore has the potential to become an important tool for determining the role of QSM as a diagnostic and monitoring tool of age-related neuropathologies. In order to be able to translate the ex-vivo QSM findings to in-...
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ژورنال
عنوان ژورنال: PeerJ
سال: 2016
ISSN: 2167-8359
DOI: 10.7717/peerj.2632